https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/children-teens.html or the best protection, CDC recommends COVID-19 vaccines for everyone 6 months and older and boosters for everyone 5 years and older, if eligible. 6 Things to Know about COVID-19 Vaccination for Children 1. COVID-19 vaccination for children is safe. Before recommending COVID-19 vaccination for children, scientists conducted clinical trials. Then, the U.S. Food and Drug Administration (FDA) determined COVID-19 vaccines are safe and effective for everyone 6 months and older.